Will DIM interact with my Birth Control (OCP)?

First of all, the metabolism of estrogen and other hormones in the body varies between individuals for a number of reasons. That said, the evidence is inconclusive as to whether DIM interacts with OCP or YAZ specifically (and other medications that use the same metabolic pathway – there are many) . Current literature suggests dosages of 200-300mg per day to be relatively low risk for interactions and possibly efficacious for various claims for which DIM is marketed. However, lack of evidence does not mean there cannot be an inhibitive effect or competitive absorption. For example,  both DIM and YAZ are metabolized primarily by the liver, but so are cruciferous vegetables like broccoli, cauliflower, cabbage, and Brussel sprouts. The active ingredient in DIM is an extract from a constituent found in cruciferous vegetables. So given the consumption of these vegetables in the population at large, it is not likely a concern. In fact, I cannot think of a medication offhand that warns against potential interactions with broccoli or the likes😊… On the other hand, if avoiding pregnancy is your primary concern, do not take DIM – better safe than sorry and for that matter, it is not likely the end all be all solution to the issue for which you are taking it, so probably not worth the uncertainty in your contraception methods. If you are really wanting to include DIM in your regular supplement regimen, then you may want to consider other options for contraception in the future. None are without risk, but non-hormone secreting IUD is one of the least risky (save for a very low percentage who experience displacement of their IUD. Although the percentage is much lower than risks associated with other major complications and OCP use).

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